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Externally introduced arginase analogs can inhibit T cells antitumor activity by reducing the arginine level in the tumor microenvironment, just as the tumor or immunosuppressive cells expressing arginase 1 can

Na + -dependent glutathione transporters are found on the luminal side of the capillary endothelial cells of the brain, kidneys, and small intestine while its presence on the luminal side of the capillary endothelial cells of other organs is very minimal

However, they work through different receptor systems and have different drug profiles

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Leaking of injection fluid can cause a persistent discoloration of skin