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Patients with diabetic kidney disease (DKD) exhibit pronounced gut microbiota dysbiosis, characterized by decreased abundance of commensal bacteria and increased prevalence of uremic toxin-producing bacteria (98) demonstrated that Roseburia intestinalis was significantly decreased while Bacteroides stercoris was markedly increased in the gut of biopsy-proven diabetic nephropathy patients, and this dysbiosis was closely correlated with parameters of lipid metabolism, glucose metabolism, and renal function

Within controlled experimental systems, BPC-157 has been studied in relation to peptide signalling mechanisms involved in cellular communication, angiogenic pathway research, and structural protein interactions

doi: 10.1016/j.pbi.2025.102705 26 ChenSGlawischnigEJrgensenKNaurPJrgensenBOlsenCEet al