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Research in this area is preliminary, and is still ongoing

Morphological changes in dendritic spines associated with long-term synaptic plasticity

One in five Americans lives with a mental illness, according to figures from the National Institute for Mental Health

As a mitigation strategy, if the test for period effect post unblinding was significant, then the statistical model for the primary outcome had to be recomputed only on the data from the first period of the trial (where period effect is taken out)as recommended by clinical practice (3537)

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2002 , CD001447 (2002)