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4.8 Cross-disease effects of luteolin on folliculogenesis and oocyte quality Follicular development and oocyte quality depend on the integrity of the granulosa-oocyte unit, which is highly sensitive to oxidative stress, mitochondrial dysfunction, and apoptotic signaling (Wu D

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Additionally, redox reactions are regulated by the oxidoreductases Trx and Grx, which are specific targets of signal transduction pathways associated with the stress response (Jimnez et al., 2024)