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NAC has been used clinically for decades as an FDA-approved drug for acetaminophen overdose (where it replenishes hepatic glutathione) and as a mucolytic agent [18]

In the first reaction, NADPH is consumed by AR, which can result in OxS since NADPH is required for reducing GSSG to GSH (by GR) and GSH is required for the reducing peroxides by the GPX system (see Figure 2)