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In IPF, mitochondrial dysfunction, including reduced mtDNA copy number and impaired oxidative phosphorylation, has been implicated in epithelial cell injury and fibrosis (Bueno et al., 2015

Spike is a tragic figure, but at least he's having some fun

Cell 166 , 555566 (2016)

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International data, although more limited, suggest similar trends in other high-income settings 6

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