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Reductions of E3 ligase function may cause APP accumulation and A generation, whereas, overexpression of these E3 ligases may result in decreased level of A in in vitro models

To maintain the intracellular redox balance, GSH is replenished through the reduction of GSSG by glutathione reductase enzyme

2.5 Enhanced capability for DNA repair DNA damage response (DDR) is an evolved series of mechanisms present in cells to tackle varied forms of DNA damage like DNA lesions, single-/double-strand breaks (SSBs or DSBs), cross-linking between or intrastrands, and even chemical modifications