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The method of any one of embodiments 39-58, wherein the composition comprises between about 0.0001% to about 20% by weight of the therapeutic agent, about 0.0001% to about 15% by weight of the therapeutic agent, about 0.0001% to about 10% by weight of the therapeutic agent, about 0.0001% to about 5% by weight of the therapeutic agent therapeutic agent, or about 0.0001% to about 1% by weight of the therapeutic agent

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Barrier Function The stratum corneum the outermost skin barrier benefits from copper peptide-induced improvements in lipid synthesis

IL-1 induces MMP-2/9-mediated degradation of basement membrane collagen (106)

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