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PTSD+MDD ( n = 7) participants had 30% higher ( p = 0.015) MPO concentrations compared to PTSD only participants ( n = 18)

The mitochondrial membranes are rich in polyunsaturated fatty acids, making them highly susceptible to a specific type of oxidative damage known as lipid peroxidation

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Demethylation therapy may lead to cytotoxicity and various side effects, while optimizing the dosage and treatment duration for MAT-targeted therapy, improving drug delivery methods, and addressing potential drug resistance issues require further investigation