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For example, GSH-supported formation of Cu + or Fe 2+ can promote Fenton-like reactions that convert H 2 O 2 into highly reactive radicals, thereby damaging cellular macromolecules and promoting multiple forms of cell death 181,182

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Moreover, components of retrograde menstruation, including heme, iron ions and apoptotic endometrial cells, are known to induce oxidative stress, intensifying the inflammatory response (15)

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36 This peptide has been explored in some regenerative protocols for osteoarthritis, often in combination with HA or platelet-rich plasma (PRP)