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The cystine/glutamate antiporter system xc in health and disease: from molecular mechanisms to novel therapeutic opportunities
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[DOI] [PubMed] [Google Scholar] 88.Manarin G., Anderson D., Silva J.M.E., da Silva Coppede J., Roxo-Junior P., Pereira A.M.S., Carmona F
This neurodegeneration is accompanied by the formation of characteristic Lewy bodies, which are intracellular inclusions composed largely of aggregated and misfolded -synuclein ( This degeneration of dopaminergic neurons is strongly linked to the generation of reactive oxygen species and oxidative stress as well as mitochondrial dysfunction, neuroinflammation, and aging (Smeyne and Smeyne, 2013)
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