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Myc can induce the upregulation of GS by enhancing the transcriptional activity of its target, thymine DNA glycosylase (TDG)

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Not preventing need for surgery or dramatically changing outcomes

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Many enzymes of DNA replication and repair (helicases, nucleases, glycosylases, demethylases) and ribonucleotide reductase use Fe as an indispensable cofactor for functioning (92)

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