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only one involved humans in a musculoskeletal context

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Frontotemporal dementia: Causes the degeneration of the frontal and temporal lobes of the brain, due to the buildup of tau proteins or TDP43 proteins

Once in the cortex, upregulation of KCC2 is necessary for the reduction of interneuron motility through the drop of neuronal chloride, a process which is also a precondition for the inhibitory effects of the neurotransmitter GABA and glycine in the CNS (Yeo et al., 2013)

Other risk factors include certain gastrointestinal conditions, autoimmune conditions such as pernicious anaemia, long-term use of some medications, and increasing age