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50,51 Recent metabonomics retrospective studies had shown that increased plasma levels of BCAAs are associated with an increased risk of pancreatic cancer, which was validated in a genetically engineered mouse model of pancreatic ductal adenocarcinoma (PDAC)

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Overexpression of cysteine dioxygenase reduces intracellular cysteine and glutathione pools in HepG2/C3A cells