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Kim HK, Biessels GJ, Yu MH, Hong N, Lee Y-H, Lee B-W, et al

New evidence also shows that TDO is overexpressed in uveal melanoma and breast cancer, and correlates with a poor prognosis in breast cancer, which suggests that TDO may be a new target for cancer immunotherapy (Liu et al., 2020

Dietary interventions, such as supplementation with specific flavonoids (e.g., ligustrazine II), can ameliorate metabolic disorders and alleviate depressive symptoms by reshaping the gut microbiota, increasing SCFAs production, and reducing systemic and neuroinflammatory responses (Luo et al., 2025)

There is limited evidence on how high B12 levels impact pregnancy, however, elevated levels could be related to underlying health issues, so its important to discuss with a doctor if youre pregnant 18

doi: 10.1016/j.expneurol.2022.114060 161 KimYKShinC