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Gene signatures and scoring Details of all gene signatures are provided in Supplementary Data

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Nef also activates NADPH oxidase through the Vav/Rac/PAK pathway in phagocytes, amplifying neuroinflammation and promoting myelin injury and neuronal damage [134, 140]

This condition affects red blood cell production, leading to fatigue and weakness

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In 2010, the first human trial using RNAi technology was conducted to evaluate the therapeutic effect of siRNA for targeting the M2 subunit of ribonucleotide reductase in patients with melanoma