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10.15585/mmwr.mm6919a2 MMWR Morb Mortal Weekly Rep

In certain embodiments, any controlled-release otic formulation described herein increases the exposure time of an active agent and decreases the C max in otic fluids (e.g., endolymph and/or perilymph) by about 40%, about 30%, about 20%, or about 10%, compared to a formulation that is not a controlled-release otic formulation

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Research confirms that glutathione concentrations in cells are measurably lower in older adults than in younger adults

doi: 10.1016/j.ajpath.2018.12.016 48 WangWUzzauSGoldblumSEFasanoA

The gut microbiota metabolite capsiate promotes Gpx4 expression by activating TRPV1 to inhibit intestinal ischemia reperfusion-induced ferroptosis