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Individuals with AVED have a mutation in their alpha-TTP that prevents it from functioning correctly

Learn More Macherey-Nagel Protino Glutathione Agarose 4B for GST-tag Protein Purification Description Protino Glutathione Agarose 4B is an affinity chromatography medium that enables fast, single-step purification of glutathione-S-transferase (GST) fusion proteins and other glutathione-binding proteins

Research-Referenced Functional Attributes (Based on existing preclinical and literature datanot intended as claims of therapeutic use) High-affinity binding to HGF and potentiation of c-Met activation in the presence of subthreshold HGF concentrations in cellular assays (DOI: 10.1124/jpet.114.218735) Induction of synaptogenesis and dendritic spine formation through HGF/c-Met pathway augmentation in neuronal models Observation of PI3K/AKT signaling modulation in APP/PS1 mouse models (DOI: 10.3389/fnagi.2021.748253) Investigation of neuroregenerative signaling mechanisms in scopolamine-induced impairment paradigms Examination of synaptic protein expression markers in aging or stress-challenged experimental systems Examination of oral bioavailability and blood-brain barrier penetration in rodent studies

GLU, glucose

doi: 10.1016/j.cellsig.2020.109820 69 ReynoldsMRLaneANRobertsonBKempSLiuYHillBGet al

The vitamin has low toxicity, so supplementation carries minimal risk, but also likely provides no benefit if stores are adequate