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[18] The FDA determined that the applications lacked sufficient evidence to show that permitting the marketing of these products would be appropriate for the protection of the public health

However, diagnostic procedures, such as characterization of anion gap (or osmolal gap, defined as the discrepancy between the measured and calculated osmolalities) (Lim et al., 2014), and evaluation for the presence of lactic acidosis, could be of potential value in suspected cases of high-dose PG toxicity from extensive vaping

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