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Reducing the harm caused by abiotic stress to plants by the exogenous application of specific treatments has gradually become a key hotspot for research [41]

Ni et al., 2020)

Moreover, local intracellular accumulation and receptor-independent actions may require higher pharmacological concentrations of melatonin to engage redox-sensitive pathways such as NRF2 compared with approaches which target the central nervous system

32 Even oral intake of high doses of glutathione does not lead to high enough serum levels to be of therapeutic value

Then NFB can translocate to the nucleus and induce the expression of target genes

doi: 10.1074/jbc.M805586200