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14 Nicotine undergoes additional metabolism through glucuronidation, catalyzed primarily by UGT2B10 15 to form nicotine glucuronide (Nic-Gluc) and oxygenation by flavin monooxygenases (FMOs) including FMO1 and FMO3 16 to form nicotine-N-oxide (NOX)

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doi:10.1038/nmeth.4637

Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hot spots in P53