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IBD is marked by chronic inflammation of the GI tract and is associated with dysbiosisan imbalance between the guts aerobic and anaerobic bacterial communities

This value may be high in times of dehydration or polycythemia, which is the overproduction of hemoglobin

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For instance, MM-131, a bispecific anti-MET/EpCAM mAb, has been developed to inhibit cell proliferation and migration in c-Met positive/HGF-positive tumors, which also overexpresses EpCAM [109]

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Notably, we generated various N-terminal truncation constructs for SnCE1, i.e., SnCE1 74-310 , SnCE1 85-310 , SnCE1 95-310 and SnCE1 104-310 , the catalytically inactive mutant SnCE1 C256A and the reported gatekeeper mutant SnCE1 W191A (Fig