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At least, four mitochondrial dehydrogenases are activated by calcium ions ( As mentioned above, ROS promote Ca 2+ release from the mitochondria ( 2+ , forming a vicious cycle: ROS enhance cytosolic concentrations of Ca 2+ , and Ca 2+ enhance ROS (and RNS) generation
ROS can modify sperm proteins through the oxidation of amino acid side chains, leading to the formation of carbonyl groups and disulfide bonds
Moreover, the combination of nanomaterials and hydrogels with plant bioactive metabolites further enhances the therapeutic effect, suggesting that PCs hold great promise for the treatment of DFU
The highest pLDDT value of 70 is found in D909 (on a scale of 0100), which corresponds to a ~0.7 probability of correct angles
