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Recent studies have also shown that RAGE and AGE-modified proteins are expressed in human ovarian tissue [35, 63]

For instance, large amino acid-mimicking glutathione-CQDs exhibit high physiological stability, reduced protein corona formation due to steric amino acid shielding, and excellent water solubility, enhancing their suitability for intravenous administration while mitigating unintended biological interactions [188]

Genetic factors, particularly variations in urate transporter genes, significantly influence individual susceptibility to hyperuricemia

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