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Because OA with multiple comorbidities was excluded from this trial, the baseline QoL was excellent, making improvement difficult

The STEP trial program alone included multiple large-scale, randomized, double-blind, placebo-controlled trials with thousands of participants

Consequently, the application of these biomarkers in routine clinical settings should be approached with caution, and further research is needed to determine their true value in guiding diagnosis, treatment selection, and disease monitoring

Daiber A

Using Mendelian randomization analysis to determine the causal connection between unpleasant emotions and coronary atherosclerosis

[PubMed]11