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The pinch
Many other factors can upregulate the expression level and activity of arginase, such as lipopolysaccharide, TNF-, glucose, thrombin, hypoxia and angiotensin II [reviewed in Pernow and Jung (2013)]
In addition, metabolites associated with amino acid metabolism and redox balance, such as lysine, arginine, and spermine, display multiple interactions with other metabolic nodes
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A long action profile supports a single weekly subcutaneous injection , and a stepwise dose increase helps keep tolerability high while the body adjusts [3] [4]