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When the -helices of PrPc refold into -sheets, this gives the pathogenic PrPsc misfolded variants, and then the prion proteins become pathogenic, resulting in neurodegeneration ( 7 Akkermansia , butyrate, GLP-1, diabetes and obesity In this section, we will describe the role that the gut microbes, particularly Akkermansia muciniphila , play in protecting the host from diabetes and obesity, via the release of a protein that induces the secretion of glucagon-like peptide 1 (GLP-1) from intestinal L-cells (Rodrigues et al., 2022)

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One such possible intervention is fasting, which has shown potential promise as an effective intervention in alleviating symptoms of neurodegenerative diseases including AD and Parkinsons disease 44,45,46,47

Peptide Dihexa was developed by researchers to provide a treatment method for neurodegenerative disorders such as Alzheimers disease and Parkinsons disease