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Accordingly, it can be assumed that the deubiquitination of arrestin alters cellular environments that are optimized for signaling, thereby diminishing signaling efficiency

Are there clinical features of liver disease, myeloproliferative disorder (e.g., blood film changes of unexplained cytopenia, thrombocytosis, or leukocytosis), or another cancer (e.g., cachexia, constitutional symptoms fever, weight loss, night sweats)

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