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[11] In practice, the benefit of treating a true B deficiency in pregnancy, preventing anemia and neurological injury, is considered to far outweigh any theoretical risks, under the guidance of a healthcare professional
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This rapid clearance is one of its key safety features in a research context
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Investigators are particularly interested in determining the mechanisms by which effects observed in murine models relate to broader mammalian metabolic regulation, and whether different experimental conditions (young vs aged models, healthy vs metabolically compromised states) show differential responses to NNMT inhibition
