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Harris research team and co-authors on the paper include Joseph Palmer, a graduate student in the UAB Department of Biology, and Autumne Lee, an undergraduate student in the UAB Department of Biology.

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Unlike signal peptides (e.g., palmitoyl pentapeptide-4) that primarily stimulate collagen synthesis, or carrier peptides (e.g., manganese tripeptide-1) that facilitate mineral transport, GHK-Cu functions as a copper transporter with direct antimicrobial activity

Therefore, the transient elevation of glutathione or the derived dipeptides following supplementation over 2 weeks may indicate stimulation of specific signaling factors that lead to elevated AMPK and PGC-1

Stress, environmental pollution, diseases, inflammations or an unbalanced diet can also lead to an increased glutathione consumption in the cells

Biochim Biophys Acta, 2013