glutathione redox and peroxisome homeostasis GSSG plays an essential role in cellular redox balance The Key Role of GSH

The millimolar GSH intracellular concentrations, the low plasma micromolar concentrations and the low GSH redox potential ( E 0 = 240 mV) make GSH an ideal and perfect cellular redox buffer (Figure 2) ( FIGURE 1 FIGURE 2 Glutathione is synthesized in the cytosol of all cells from their precursor amino acids: glutamic acid, cysteine and glycine by consecutive action of two enzymes: -glutamyl-cysteine (-GluCys) synthetase (also known as glutamate cysteine ligase, GCL) that in a first step uses glutamate and cysteine as a substrate to form the dipeptide -glutamyl-cysteine

FASEB J (2015) 29(12):476671

Weight Gain: Rarely, receiving large doses of glutathione injections may also result in weight gain

Ecole Polytechnique Federale de Lausanne (EPFL) and Nestle carried out the study

and M.C

J.et al (2015)