The lactate leads to acidification of the environment and stabilization of activated HIF-1 in the interior region which then reinforces glycolysis in the interior region by upregulating GLUT1, LDHA, and hexokinase 2 (HK2), key proteins involved in the glycolytic pathway
DAC (Drug Affinity Complex) is a modification that lets the peptide bind to albumin in your blood, extending its half-life from ~30 minutes to ~8 days
The figure describes an in-vitro dendritic-spine assay in which picomolar Dihexa produced spine density comparable to nanomolar BDNF a potency ratio in a specific cell-culture readout
It's built on science
Gii c c th Glutathione tham gia vo qu trnh gii c gan, gip loi b c t, kim loi nng v cc cht gy hi khc ra khi c th
Yu X, McCorkle S, Wang M, Lee Y, Li J, Saha AK, Unger RH, Ruderman NB (2004) Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition