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Published clinical data supports accelerated initial response with the combination approach

[6] After deep intramuscular injection the lipophilic ester diffuses slowly from the oil depot, undergoes enzymatic cleavage to free testosterone and enters the systemic circulation, where roughly 98 % is reversibly bound to sex-hormone-binding globulin and albumin while the unbound fraction translocates across cell membranes to activate androgen receptors

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Astrocytes also have a distinct role in contributing brain immunosurveillance, having the capability to present antigens and produce cytokines and may affect BBB permeability to allow entry of circulating T cells into the brain [47]