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When it comes to the brain, estrogen receptors are located in several regions like the hippocampus and prefrontal cortex

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Do not double up on doses as this can lead to an overdose

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SAMe ultimately plays a role in numerous methylation reactions catalyzed by methyltransferase enzymes including the synthesis of hormones, neurotransmitters, nucleic acids, proteins, and phospholipids (Mischoulon)