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In practice, stacking multiplies uncertainty: more compounds more chances of impurity/contamination more pathways affected more interaction risk more variables harder to know what helped (or harmed) If you take only one clinical principle from this article: the more experimental the stack, the more conservative your risk posture should be

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Efficacy and safety of Oxalobacter formigenes to reduce urinary oxalate in primary hyperoxaluria

doi: 10.3389/fphar.2023.1321880 130

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