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It provides a logical explanation for the development of dual targeting drugs such as MM-131 a bispecific anti-MET/EpCAM mAb [108] and also further drug discoveries targeting concurrently all three c-Met, EpCAm and Wnt pathway simultaneously to overcome both innate and acquired resistance to tyrosin kinase inhibitors (TKIs)

To compare the blood stability of Norleual and D-Nle-Tyr-Ile-NH(CH 2 ) 5 CONH), a representative member of the 6-AH family, 20 L of compound-containing vehicle (water [Norleual] or 30% ethanol [D-Nle-Tyr-Ile-NH(CH 2 ) 5 CONH 2 ]) was added to 180 L of heparinized blood and incubated at 37 C

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