mTOR regulates the proliferation and activation of B lymphocytes B cells participate in the pathogenesis of RA by producing autoantibodies, proinflammatory cytokines, and chemokines, acting as efficient antigen-presenting cells and regulating T cell activation and differentiation [69, 70]
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Resultantly, the protein could be misfolded or subjected to erratic post-translational modification, ultimately being more susceptible to proteolysis and other forms of degradation in the RBC (88)
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