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The secondary endpoints of the study included pharmacokinetic parameters such as plasma concentration over time, maximum concentration, half-life, plasma clearance, and volume distribution of cagrilintide and semaglutide

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In 3T3-L1 cells, expression of TGH is upregulated tenfold upon differentiation of preadipocytes into adipocytes (25) due, at least in part, to transcriptional regulation by the adipogenic transcription factor C/EBP (136)

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Those proteins are broken down with enzymes into a mix of small peptides and free amino acids

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