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Emerging clinical and preclinical findings further suggest that microbiota alterations precede the onset of PD motor symptoms and may drive neurodegeneration via systemic inflammation and microglial activation [176]

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10.1096/fj.04-2833rev FASEB J

That showed basically binding of either dynorphin or whatever ligand to the kappa opioid receptor, basically sensitizes the Mu opioid receptor to the feel-good endorphins, and also changes