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The HDACs are well known to control multiple vital biological processes such as cell proliferation, differentiation and development by binding to many transcription factors and transcription co-regulators ( Till date, total eighteen mammalian HDACs are well characterized and grouped into four major classes based upon their homology to yeast histone deacetylases ( Figure 3 )
doi:10.1172/jci116842 Pickart L, Vasquez-Soltero JM, Margolina A
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Hohla F, Schally AV
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