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According to data from the World Health Organization, approximately 225,000 new ovarian cancer cases are reported globally each year, with HGSOC accounting for the vast majority, and its mortality rate ranking among the highest of all gynecological malignancies ( HGSOC is typically diagnosed at an advanced stage, a phenomenon that results in an extremely poor prognosis, as the absence of early diagnosis and effective treatment contributes to a continuous increase in mortality rates ( The clinical manifestations of HGSOC are typically not apparent in the early stages, with patients potentially experiencing non-specific symptoms such as abdominal distension, abdominal pain, decreased appetite, and weight changes, which render early diagnosis particularly challenging
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This exchange process represents a significant molecular trigger for ferroptosis initiation ( Intracellular cystine is reduced to cysteine, the key precursor for GSH synthesis, while NADPH from the pentose phosphate pathway supplies reducing equivalents for this antioxidant system
Glutathione deficiency is associated with impaired survival in HIV disease Hong, K.S., et al
Shergill, I
