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Validating urine-based biomarkers (e.g., glomerular cell-derived exosomal ferroptosis regulators, and 4-HNE metabolites) or circulating signatures that correlate with IgA nephropathy disease activity, pathological severity, or response to interventions is urgently needed to guide clinical trial design and patient stratification

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It is important to note that the interpretation of a fasting insulin test may vary depending on the individual's medical history and other factors

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