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However, this issue requires more clinical studies to determine the appropriate dose and confirm its effectiveness in treating this disease

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10.18632/oncotarget.23498 13 ChenP.TangH.ZhangQ.XuL.ZhouW.HuX.et al (2020)

Given the timescale required to observe tangible effects with immunomodulation in general, it is probably not surprising that many studies fail to correlate rapid antidepressant onset with immediate reductions in cytokine activity