According to Ma and Farny (2023), senescence phenotypes in post-mitotic neurons cellular senescence are pronounced in enhanced activity of senescence-associated beta-galactosidase (SA--gal), cell cycle arrest [P53-P21 pathway and P16 pathway integrate to RB (retinoblastoma) hypophosphorylation], DNA damage, elevated RB hypophosphorylation, SASPs, and also senescence-associated heterochromatic foci (SAHFs), promoting cell cycle arrest (Ma and Farny, 2023
Enzymes from the cycle are also central for the mechanisms of drought adaptation and tolerance in xerophyte plants
-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinsons disease from multiple system atrophy
Schleicher, E., Didangelos, T., Kotzakioulafi, E., Cegan, A., Peter, A., & Kantartzis, K
828, ISBN 978-1-84973-670-1, OCLC 825559753 (ang.)
Elevated levels of ROS can lead to a decrease in NO levels and impaired endothelial cell function