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Cerebellar tDCS modifies the excitability of the cerebellar cortex with minor side effects (mainly burning or itching sensation)

[2] The reasoning behind the local designation was structural as much as functional: because the E-domain reading-frame shift alters the C-terminal sequence, the variant was predicted to interact differently with the binding proteins present in muscle interstitial spaces, keeping its action localized and its half-life short

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Since glutamate is one of the brains major excitatory neurotransmitters, this pathway has drawn interest in conditions such as obsessive-compulsive disorder (OCD), depression, bipolar disorder, and substance use disorders.11 29 The evidence is still uneven