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CYP24A1, a gene that provides instructions for making the enzyme 24-hydroxylase, is involved in the catabolism of both 25(OH)VD 3 and 1,25(OH) 2 D 3, thereby limiting vitamin D receptor (VDR)/1,25(OH) 2 D 3 signaling 14

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Given that orally administered prebiotics and postbiotics have been shown to improve pulmonary health in calvespotentially through modulation of the gut lung axisthe oral microbiome, as a nodal point within this axis, represents an accessible intervention point warranting further investigation in bovine-specific models