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What is supported in animal models Increased lipolysis, increased fat oxidation, decreased lipogenesis, no apparent effect on plasma glucose or insulin sensitivity, and signal that intact beta-3 adrenergic receptor activity matters for the fat-loss effect

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Journal of Clinical Pharmacology, 55(12), 1459-1465

Kidney failure and liver damage: Untill now, studies in patients with liver damage or renal failure did not detect pharmacokinetic differences, in normal individuals

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