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The evidence might be the relaxation noted in the aorta without endothelium ex vivo as opposed to the lack of relaxation directly on the 3-D model composed of vascular smooth muscle cells (unlike the effect of NO-donor sodium nitroprusside) [61]
Before advancing these strategies to clinical application, several key challenges must be addressed, such as the complexity and functional redundancy of the ferroptosis regulatory network, the limitations of existing animal models in simulating the pathological features of human chronic OA, and the lack of reliable biomarkers for assessing intra-articular ferroptosis activity in humans
K.LascanoG.ParysC.HelmbrechtA.et al
doi: 10.1016/j.immuni.2014.04.007 131 CraveiroMCretenetGMongellazCMatiasMICaronOde LimaMCPet al
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