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Incidence Data emerging from randomized clinical trials (RCTs) shows that the frequency and the incidence of irAEs usually depend on the ICI agent used, duration of exposure, dose and patients risk factors profile

As a new type of topical dosage form, it significantly accelerates the healing of burns, trauma, diabetic ulcers and inflammatory bowel disease through multiple mechanisms such as promoting angiogenesis, inhibiting inflammatory responses, accelerating cell proliferation and antioxidation and antiapoptosis

10.1093/hmg/ddq288 Hum

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The risk increases with deeper peels, aggressive cryotherapy, or if you pick at the treated area during the healing process