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Chlorogenic acid for cancer prevention and therapy: current status on efficacy and mechanisms of action

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10.1016/j.tox.2008.11.006 Toxicology 66 TashiroK.AsakuraT.FujiwaraC.OhkawaK.IshibashiY

doi: 10.1039/D3FB00236E 103

[U- 13 C]glutamine isotope tracing experiments showed that GGCT overexpression reduced Gln contribution to the TCA cycle and diverted it preferentially to the GSH synthesis pathway for ROS regulation

Excessive ROS attacked intracellular lipids and proteins, resulting in the formation of MDA and PC, inducing oxidative stress and leading to tissue damage [42, 43]